Optic Glioma / Optic Nerve & Growth Factor Eye Drops

Optic Gliomas Respond to Growth Factor Eye Drops

Optic gliomas are rare  tumors of the brain targeting one or both optic nerves or location where the two optic nerves cross each other, the optic chiasm.  This condition is not known to get better naturally, although nerve growth factor eye drops could help in milder causes.  So far, the results are limited and more research is needed.

The study was  published in Neurorehabilitation and Neural Repair, involved a single 45 year old female with an optic gliomas and who also had had optic nerve atrophy for some time. She was given the nerve growth eyedrop for 2 months and there was some improvement.  Two months after the treatment stopped her vision seemed to get worse.

The study conclusion was that this type of eye drop might yield promising results in the future. There were no noted side effects as a result of the treatment.

Source: Neurorehabilitation and Neural Repair, February 22, 2011

Optic Nerve Helped by Growth Factor Eye Drops

Findings of another study  using nerve growth factor are promising for treating optic nerve caused blindness and  for spurring regeneration in the spinal cord and brain. The researchers reported that they’d  found a previously unknown, naturally occurring,  growth factor that stimulates regeneration in damaged optic nerves.

The growth factor is called a calcium binding protein called oncomodulin.  When researchers studied it’s effects on in-vitro nerve cells from the retina, and while other already-known growth factors were included, optic nerve cell grew by two times.  Oncomodulin was more potent than the other growth factors.

More Nerve Regeneration

Animal research was also performed and it was found that sustained-released oncomodulin (supplied from tiny capsules) increased nerve regrowth by 5-7 times.  A drug that helps nerve cells responde to oncomodulin was also given to the lab rats.  The process apparently involves activating genes connected to nerve cell growth.

“Out of the blue, we found a molecule that causes more nerve regeneration than
anything else ever studied,” said one of the study investigators. We expect
this to spur further research into what else oncomodulin is doing in the nervous
system and elsewhere.

The data are published in the May 14 online edition of Nature Neuroscience.