Chronic Fatigue

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Central Nervous System and Hormone Abnormalities

Abnormalities in the central nervous system, including pinpoint spots of brain inflammation and abnormal levels of certain hormones have been reported in a number of patients with CFS, but similar findings have also been found in those without the illness.

Abnormalities in the Hypothalamus-Pituitary-Adrenal Axis

Of particular interest to researchers are higher incidences of abnormalities in the brain system known as the hypothalamus-pituitary-adrenal axis. This system produces or regulates hormones and brain chemicals that control important functions, including sleep, response to stress, and depression.

Stress Hormone Deficiencies

A number of studies on CFS patients have observed deficiencies in cortisol levels, a stress hormone produced in the hypothalamus. Deficiencies may be the reason why CFS patients have an impaired and weaker response to psychologic or physical stresses (such as infection or exercise).

Abnormalities in Neurotransmitters

Other research has reported that some patients with CFS have abnormally high levels of serotonin, a neurotransmitter (chemical messenger in the brain). Such elevated levels in the brain are associated with fatigue. Yet another study reported that deficiencies in dopamine, another important neurotransmitter, may play a role in CFS.