Contains a number of natural anti-inflammatories shown in studies to help reduce inflammation.
Serving size 4 capsules:
Number of servings per container 30
Ingredients are as follows:
Suggested Dose: Take 1-2 capsules with each meal and before bed, or as directed by your health care practitioner.
The effect of niacinamide on osteoarthritis: a pilot study
In one double-blind study of men, niacinamide supplementation (500 mg six times per day for 12 weeks) significantly increased joint range of motion and significantly decreased the erythrocyte sedimentation rate, suggesting support for healthy inflammatory balance.
Ref: Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide on osteoarthritis: a pilot study. Inflamm Res 1996;45:330-334.
Long-term effects of glucosamine sulphat on development of osteoarthritis: a placebo-controlled, trial that evaluated changes in joint structure and symptoms of osteoarthritis.
The study evaluated 212 patients with knee osteoarthritis who, randomly, were given 1500 mg sulphate oral glucosamine or a placebo to be taken daily over the course of 3 years.
The study concluded that the long-term effects of glucosamine sulphate suggest that it could be helpful for osteoarthritis patients.
Ref: Lancet. 2001 Jan 27;357(9252):251-6.
Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis
Another 3-year, random, double-blind, and placebo-controlled research study looked at more than 200 patients who had osteoarthritis of the knee. They were randomly scheduled to receive 1500mg of glucosamine sulfate daily or a placebo.
The reseachers concluded that treating the condition with glucosamine sulfate over a long period did slow the progression of osteoarthritis.
Ref: Arch Intern Med. 2002;162(18):2113-2123. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-162-18-ioi10873.
Efficacy of methylsulfonyl-methane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
Another 2004 clinical trial, also double-blind, randomized, and placebo-controlled evaluated the benefit of distilled MSM on mild to moderate knee osteoarthritis. The osteoarthrtis patients received 3,000 mg of MSM twice a day or placebo for about 3 months.
The researchers found that the patients receiving MSM had statistically significantpain reductions and significant reductions in their difficultyin performing daily activities.
Ref: Osteoarthritis and Cartilage 2006;14:286-94.
Symptom-modifying effect of chondroitin sulfate in knee osteoarthritis: a meta-analysis of randomized placebo-controlled trials performed with structum(®)
Another study performed a meta-analysis of randomized double-blind placebo-controlled clinical trials to assess the efficacy of a specific chondroitin sulfate preparation as a symptom-modifying drug in osteoarthritis of the knee.
The study results demonstrated that this chondroitin sulfate preparatio was effective on symptoms in patients with OA of the knee compared to placebo, and may therefore have a role in the management of patients with knee osteoarthritis of Kellgren-Lawrence grades II and III.
Ref: Rheumatol J. 2012;6:183-9. Epub 2012 Jul 25.
Efficacy and tolerability of Boswellia serrata extract (BSE) in treatment of osteoarthritis of knee a randomized double blind placebo controlled trial.
Boswellia serrata tree is known to posses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata Extract (BSE) in 30 patients of osteoarthritis of knee.
The study results showed that the frequency of swelling in the knee joint was decreased, though radiologically there was no change. Boswellia serrata was shown to be well tolerated, and BSE was recommended in the patients of osteoarthritis of the knee with possible therapeutic use in other arthritis.
Ref: Phytomedicine. 2003 Jan;10(1):3-7.
Effects of a ginger extract on knee pain in patients with osteoarthritis
This study evaluated 261 patients with Osteoarthritis (OA), analyzing the efficacy and safety of a standardized and highly concentrated extract of 2 ginger species Zingiber officinale and Alpinia galangal supplementation. In this randomized, double-blind, placebo-controlled, multicenter, parallel-group, 6-week study, patients received ginger extract or placebo twice daily, with acetaminophen allowed as rescue medication.
The study conclusion was that supplementing with a highly purified and standardized ginger extract had a statistically significant effect on reducing symptoms of OA of the knee. This effect was moderate. There was a good safety profile, with mostly mild GI adverse events in the ginger extract group.
Ref: Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538.
CASE STUDY #1463: A Case Study Evaluating the Effects of a Combination THIAA, Rosemary Extract, and Oleanolic Acid Nutraceutical in a Patient with Osteoarthritis
The purpose of this study was to evaluate whether the nutraceutical combination of tetrahydro-isoalpha acids (THIAA), rosemary extract, and oleanolic acid would alleviate discomfort in a patient with osteoarthritis (OA). This study took a 43 year old male with a 15 year history of OA in his knees.
The result suggested a distinctive clinical improvement and noticeably fewer symptoms of pain and swelling after 4 weeks. This was based on patient’s Medical Symptoms Questionnaire (MSQ)† score decreased from 25 to 6 (reference range: <30 = few or low intensity symptoms).
Ref: Robert H. Lerman, MD. Functional Medicine Research CenterSM, Gig Harbor, WA 98332
Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients
In a previous three-month study of Meriva (a proprietary curcumin-phosphatidylcholine phytosome complex), decreased joint pain and improvement in joint function were observed in 50 osteoarthritis (OA) patients. This study further studies 100 OA patients in an extended 8 month investigation.
Significant improvements of both the clinical and biochemical end points were observed for Meriva compared to the control group, and suggests that Meriva is worth considering as part of a long term approach to managing OA>
Altern Med Rev. 2010 Dec;15(4):337-44.
Cetylated fatty acids (CFA) improve knee function in patients with osteoarthritis
The study objective was to determine the benefit of cetylated fatty acids (CFA) on knee range of motion and function in patients with osteoarthritis (OA).
The results of the study was that just after 68 days compared to the placebo group, CFA provided an improvement in knee range of motion and overall function in patients with OA of the knee., and that CFA may be an alternative to the use of nonsteroi