Serving size 4 capsules:
Number of servings per container 30
Ingredients are as follows:
- Niacinamide 600 mg
- Glucosamine Sulfate (KCL stabilized) 1500 mg.
- MSM (methyl sulfonyl methane) 500 mg.
- Chondroitin Sulfate 250 mg.
- Boswellia Serrata Extract (60% Boswellic acid) 100 mg.
- Ginger Extract (5% Gingerols) 50 mg
- Rosemary 50 mg.
- Turmeric Extract (95% curcuminoids) 50 mg
- Cetyl Myristoleate 30 mg.
Suggested Dose: Take 1-2 capsules with each meal and before bed, or as directed by your health care practitioner.
The effect of niacinamide on osteoarthritis: a pilot study
In one double-blind study of men, niacinamide supplementation (500 mg six times per day for 12 weeks) significantly increased joint range of motion and significantly decreased the erythrocyte sedimentation rate, suggesting support for healthy inflammatory balance.
Ref: Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide on osteoarthritis: a pilot study. Inflamm Res 1996;45:330-334.
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial
This study assessed the effects of glucosamine sulphate on the long-term progression of osteoarthritis joint structure changes and symptoms.
This double blind, randomized control study evaluated 212 patients with knee osteoarthritis were randomly assigned 1500 mg sulphate oral glucosamine or placebo once daily for 3 years.
The study conclusion was that the long-term combined structure-modifying and symptom-modifying effects of glucosamine sulphate suggest that it could be a disease modifying agent in osteoarthritis.
Ref: Lancet. 2001 Jan 27;357(9252):251-6.
Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis
A 3-year, randomize, double-blind, placebo-controlled study evaluated two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral glucosamine sulfate, 1500 mg once a day, or placebo.
The study conclusion was that long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.
Ref: Arch Intern Med. 2002;162(18):2113-2123. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-162-18-ioi10873.
Efficacy of methylsulfonyl-methane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
In 2004, Kim et al conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the effects of distilled MSM on mild to moderate osteoarthritis of the knee. The study participants were given 3,000 mg twice daily of either placebo or MSM for 12 weeks.
The study concluded that compared to the placebo group, those taking MSM had statistically significant reductions in pain and in difficulty performing activities of daily living.
Ref: Osteoarthritis and Cartilage 2006;14:286-94.
Symptom-modifying effect of chondroitin sulfate in knee osteoarthritis: a meta-analysis of randomized placebo-controlled trials performed with structum(®)
This study performed a meta-analysis of randomized double-blind placebo-controlled clinical trials to assess the efficacy of a specific chondroitin sulfate preparation as a symptom-modifying drug in osteoarthritis (OA) of the knee.
The study results demonstrated that this chondroitin sulfate preparation (Structum®) was effective on symptoms in patients with OA of the knee compared to placebo, and may therefore have a role in the management of patients with knee osteoarthritis of Kellgren-Lawrence grades II and III.
Ref: Rheumatol J. 2012;6:183-9. Epub 2012 Jul 25.
Efficacy and tolerability of Boswellia serrata extract (BSE) in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Boswellia serrata tree is known to posses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata Extract (BSE) in 30 patients of osteoarthritis of knee.
The study results showed that the frequency of swelling in the knee joint was decreased, though radiologically there was no change. Boswellia serrata was shown to be well tolerated, and BSE was recommended in the patients of osteoarthritis of the knee with possible therapeutic use in other arthritis.
Ref: Phytomedicine. 2003 Jan;10(1):3-7.
Effects of a ginger extract on knee pain in patients with osteoarthritis
This study evaluated 261 patients with Osteoarthritis (OA), analyzing the efficacy and safety of a standardized and highly concentrated extract of 2 ginger species Zingiber officinale and Alpinia galangal supplementation. In this randomized, double-blind, placebo-controlled, multicenter, parallel-group, 6-week study, patients received ginger extract or placebo twice daily, with acetaminophen allowed as rescue medication.
The study conclusion was that supplementing with a highly purified and standardized ginger extract had a statistically significant effect on reducing symptoms of OA of the knee. This effect was moderate. There was a good safety profile, with mostly mild GI adverse events in the ginger extract group.
Ref: Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538.
CASE STUDY #1463: A Case Study Evaluating the Effects of a Combination THIAA, Rosemary Extract, and Oleanolic Acid Nutraceutical in a Patient with Osteoarthritis
The purpose of this study was to evaluate whether the nutraceutical combination of tetrahydro-isoalpha acids (THIAA), rosemary extract, and oleanolic acid would alleviate discomfort in a patient with osteoarthritis (OA). This study took a 43 year old male with a 15 year history of OA in his knees.
The result suggested a distinctive clinical improvement and noticeably fewer symptoms of pain and swelling after 4 weeks. This was based on patient’s Medical Symptoms Questionnaire (MSQ)† score decreased from 25 to 6 (reference range: <30 = few or low intensity symptoms).
Ref: Robert H. Lerman, MD. Functional Medicine Research CenterSM, Gig Harbor, WA 98332
Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients
In a previous three-month study of Meriva (a proprietary curcumin-phosphatidylcholine phytosome complex), decreased joint pain and improvement in joint function were observed in 50 osteoarthritis (OA) patients. This study further studies 100 OA patients in an extended 8 month investigation.
Significant improvements of both the clinical and biochemical end points were observed for Meriva compared to the control group, and suggests that Meriva is worth considering as part of a long term approach to managing OA>
Altern Med Rev. 2010 Dec;15(4):337-44.
Cetylated fatty acids (CFA) improve knee function in patients with osteoarthritis
The study objective was to determine the benefit of cetylated fatty acids (CFA) on knee range of motion and function in patients with osteoarthritis (OA).
The results of the study was that just after 68 days compared to the placebo group, CFA provided an improvement in knee range of motion and overall function in patients with OA of the knee., and that CFA may be an alternative to the use of nonsteroidal anti-inflammatory drugs for the treatment of OA.
Ref: J Rheumatol. 2002 Aug;29(8):1708-12.