CholesePure is a formulation by Pure Encapsulations. The formula is based on research of nutrients that may be most helpful for those with high cholesterol (see study summaries below).
Phytosterols are sterol molecules which are similar in structure to cholesterol. These nutrients are synthesized by plants and are present naturally in grains, nuts, seeds, fruits and vegetable oils. In studies, phytosterols have demonstrated the ability to modulate the absorption of cholesterol into circulation and to help maintain healthy LDL cholesterol levels. Traditional Western diets only provide about 200 mg of phytosterols per day (based on beta-sitosterol content), an amount too low to exert cholesterol support. Recent health conscious trends involve the incorporation of phytosterols into margarines and salad dressings to help enhance daily intake. CholestePure is a broad spectrum balance of the most prized phytosterols which includes: beta-sitosterol, campesterol, stigmasterol and brassicasterol..
Each VCapsule Contains:
- phytosterol complex 500 mg. (derived from soybean oil) providing: beta-sitosterol 230 mg.
- campesterol 135 mg
- stigmasterol 82 mg.
- brassicasterol 1.5 mg.
- sitostanol 1.5 mg
- vitamin C (as ascorbyl palmitate) 10 mg. (hypo-allergenic plant fiber may be added to complete capsule volume requirement)
Recommended Use: Take 1-2 vegetarian capsules with each meal, or as directed by your physician.
The information offered above is not intended as medical advice, nor intended to diagnose medical problems. Its intent is solely informational and educational. Products offered are not intended to diagnose, treat, cure or prevent any disease. Please consult a health professional should the need for one be indicated.
Note: Phytosterols are plant sterols structurally similar to cholesterol. The main ones are campesterol, sitosterol, stigmasterol, and their respective stanols (5 alpha-saturated derivatives), which chemically resemble cholesterol. Phytosterols inhibit intestinal cholesterol absorption. Fat-soluble plant stanol esters were introduced as a functional food for lowering serum cholesterol in the early 1990s. Plant sterol esters entered the market at the end of the 1990s. Inhibition of the intestinal absorption of cholesterol stimulates cholesterol synthesis, a factor which limits serum cholesterol lowering to about 10% with phytosterols.
Phytosterols lower cholesterol levels in a dose-dependent manner
Phytosterols are compounds found naturally in plants that are structurally similar to cholesterol. There are a number of good food sources including: whole grains, wheat germ, , nuts, seeds, unrefined plant and legumes. It has been recognized for many years that phytosterols reduce total and LDL cholesterol levels in humans. This is why the National Cholesterol Education Program recommends adults consume 2 grams of phytosterols daily to help protect against cardiovascular disease. This quantity is only attainable through the use of supplements or plant sterol-enriched foods.
This study was a highly controlled feeding trial in which participants consumed phytosterol-deficient diets plus supplemental beverages providing 0mg, 400mg or 2000 mg phytosterols per day. All participants rotated through the three 4-week treatment conditions in randomized order, with 1 week between treatments. Intestinal cholesterol absorption and fecal cholesterol excretion were measured under each experimental condition. The results were that the researchers found that both moderate and high intakes of phytosterols significantly increased fecal cholesterol excretion, with the higher dose having an even greater effect. In addition, high phytosterol intake significantly reduced LDL cholesterol levels, and a nonsignificant trend was observed for moderate intake.
In summary, although supplemental sources of plant sterols produce the greatest effect, even moderate phytosterol intake such as that obtained from a diet rich in plant-based foods provided cholesterol lowering effects in humans.
Ref: Racette SB, Lin X, Lefevre M, Spearie CA, Most MM, Ma L, Ostlund Jr RE. Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr; Nov. 2009.
Campesterol and Heart Disease
All individuals differ when it comes to the balance between cholesterol production and absorption. Some people synthesize cholesterol more than they absorb, while others absorb more than they synthesize.
In one study patients with coronary heart disease and/or carotid artery stenosis had significantly higher levels of campesterol and beta-sitosterol than age and gender matched controls despite similar HDL-C and LDL-C levels.
Ref: Framingham Offspring Study (2009)
Abstract 4099: Elevated Campesterol Serum Levels - a Significant Predictor of Incident Myocardial Infarction: Results of the Population-based MONICA/KORA Follow-up Study 1994 to 2005
The study goal was to assess the relationship between the serum levels of the phytosterol campesterol and the 10 year risk of incident myocardial infarction in initially healthy middle-aged men from Southern Germany with no myocardial infarction in medical history.
The study results concluded that a large prospective population-based cohort analysis demonstrated for the first time that plasma campesterol is an independent and highly significant metabolic marker indicating an increased risk for incident myocardial infarction in middle aged men.
Ref: (1) Institute of Laboratory Medicine, Univ Hosp Leipzig, Leipzig, Germany, (2) GSF - National Rsch Cntr for Environment and Health, Institute of Epidemiology, Neuherberg, Germany, Neuherberg, Germany, (3) MONICA/KORA Myocardial Infarction Registry, Augsburg Central Hosp, Augsburg, Germany, Augsburg, Germany, (4) GSF - National Rsch Cntr for Environment and Health, Institute of Epidemiology, Neuherberg, Germany, Neuherberg, Germany.
Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats
This study looked at the effects of dietary stigmasterol on sterol and bile acids metabolism. Wistar rats were fed diets containing various amounts of stigmasterol. The dosages they were fed were high stigmasterol doses (11, 26 or 52 mg/day). This led to increased cholesterol, coprostanol and bile acid output. These effects were dose-dependent, and likely to be related to the inhibitory effect of plant sterols on cholesterol absorption. Moreover, the results account for the beneficial effect of the stigmasterol on cholesterol lowering.
Ref: Ann Nutr Metab. 1989;33(5):297-303.
Spreads fortified with a brassicasterol-rich phytosterol mixture from rapeseed oil lower serum total and LDL-cholesterol concentrations in mildly hypercholesterolemic subjects
This double-blind, placebo-controlled study goal was to evaluate the cholesterol (C) lowering efficacy and the impact on plasma fat soluble vitamins, carotenoids and phytosterol (PS) concentrations of a brassicasterol-rich PS mixture from rapeseed oil.
The study conclusion was that Brassicasterol-rich PS mixtures from rapeseed oil have cholesterol lowering properties similar to those reported previously with PS from other sources and are therefore a suitable alternative for PS enrichment of foods.
Ref: The FASEB Journal. 2007;21:847.12
Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans.
This study reviewed the ability of sitostanol to reduce cholesterol absorption.
The study conclusion was that properly formulated sitostanol as well as naturally occurring complexes of phytosterol and phospholipid might be therapeutically useful for cholesterol lowering.
Ref: Am J Clin Nutr. 1999 Nov;70(5):826-31.
Vitamin C Intake & HDL Cholesterol
This study investigated the effect of vitamin C intake on total cholesterol levels. The researchers found that in a population with vitamin C intake well above the RDA of 60 mg/day, there was a significant positive association between high levels of plasma vitamin C and high levels of HDL cholesterol. In summary after adjustment for age, sex, obesity, and smoking, high plasma vitamin C was directly associated with high HDL cholesterol.
Ref: J. Hallfrisch, V.N. Singh, D.C. Muller, et al. Am J Clin Nutr. 1994;60:100-105.
Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials
Thirteen randomized controlled trials published between 1970 and June 2007 were identified using Medline and a manual search, with the goal to provide a comprehensive meta-analysis of randomized controlled trials to investigate the effect of vitamin C supplementation on LDL and HDL cholesterol as well as triglycerides in patients with hypercholesterolemia.
The conclusion of the study was that supplementation with at least 500 mg per day of vitamin C for a minimum of 4 weeks can result in a significant decrease in serum LDL cholesterol and triglyceride concentrations. However, there was a non-significant elevation of serum HDL cholesterol.
Ref: J Chiropr Med. 2008 June; 7(2): 48–58. Published online 2008 May 27. doi: 10.1016/j.jcme.2008.01.002