GlycoEase Sublingual Formula contains the following ingredients:
- Gymnema Sylvestra which has the ability to normalize blood glucose function by repairing, revitalizing and regenerating the beta cells of the pancreas.
- Vanadyl Sulfate has partially restored insulin production, protected the size and content of pancreatic islets, maintained glucose tolerance regardless of insulin levels, maintained levels of glucose, lipids, creatinine and thyroid hormone, and corrected heart function and glycerol output from adipose tissue.
- Chromium Polynicotinate reduces fasting glycemia, mean blood glucose and glycated hemoglobin.
- Niacin (B3) is vital for proper synthesis of insulin, and metabolism of carbohydrates, fats and proteins.
Recommended dosage: 8 drops under the tongue 3-5 times per day. or as specified by your healthcare professional. Swish in mouth for up to 2 minutes then swallow. Preferably taken away from meals (either 10 minutes or more before eating or 1 hour or more after eating.Consult your doctor before using.
Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus
GS4 is a water-soluble extract of the leaves of Gymnema sylvestre. In this study, GS4 was administered at400 mg/day to 27 patients with insulin dependent diabetes mellitus (IDDM) on insulin therapy. The results of the study were that insulin requirements came down together with fasting blood glucose and glycosylated haemoglobin (HbA1c) and glycosylated plasma protein levels. GS4 therapy appears to enhance endogenous insulin, possibly by regeneration and revitalization of the residual beta cells in insulin-dependent diabetes mellitus.
Ref: Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. J Ethnopharmacol 1990 Oct;30(3):281-94.
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients
This study reviewed the effectiveness of GS4 which an extract from the leaves of Gymnema sylvestre in controlling hyperglycaemia. 22 Type 2 diabetic patients on conventional oral anti-hyperglycaemic agents participated in this study. GS4 (400 mg/day) was administered for 18-20 months as a supplement to the conventional oral drugs. During GS4 supplementation the patients showed a significant reduction in blood glucose, glycosylated haemoglobin and glycosylated plasmaproteins. Conventional drug dosage was able to be decreased. Five of the 22 diabetic patients were able to discontinue their conventional drug and maintain their blood glucose homeostasis with GS4 alone. The study results suggest that the beta cells may be regenerated/repaired in Type 2 diabetic patients on GS4 supplementation. This is supported by the appearance of raised insulin levels in the serum of patients after GS4 supplementation.
Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. J. Ethnopharmacol 1990 Oct;30(3):295-300.
Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans
This study was designed to evaluate the possibility that the failure results from inadequate levels of dietary nicotinic acid to serve as substrate for GTF synthesis. 16 healthy elderly volunteers were divided into three groups and given either 200 micrograms Cr, 100 mg nicotinic acid, or 200 micrograms Cr + 100 mg nicotinic acid daily for 28 days. They were then evaluated on days 0 and 28. ]
The study results suggest that the inability to respond to chromium supplementation may result from suboptimal levels of dietary nicotinic acid.
Urberg M, Zemel MB. Metabolism 1987 Sep;36(9):896-9.
Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors
This study assessed the effects of daily supplemental chromium (200 micrograms) complexed with 1.8 mg nicotinic acid on plasma glucose and lipids, including total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides. 14 healthy adults and 5 adults with noninsulin-dependent diabetes mellitus (NIDDM) were studied using a double-blind crossover study with 8-wk experimental periods. Regarding the effects of chromium nicotinic acid supplementation, no statistically significant results were found on plasma insulin, glucose or lipid concentrations. Although chromium nicotinic acid supplementation slightly lowered fasting plasma total and LDL cholesterol, triglycerides and glucose concentrations, and 90-min postprandial glucose concentrations in individuals with NIDDM.
Thomas VL, Gropper SS. Biol Trace Elem Res 1996 Dec;55(3):297-305.
Comparison of the glucose-lowering properties of vanadyl sulfate and bis(maltolato) oxovanadium (IV) following acute and chronic administration
It has been demonstrated in both in vitro and in vivo in numerous studies the insulin-mimetic properties of vanadium. Chronic oral administration of inorganic and organic compounds of both vanadium (IV) and vanadium (V) reduced plasma glucose levels and restored plasma lipid levels in streptozotocin-diabetic rats. In this study, the goal was to investigated the acute effects of both vanadyl sulfate and bis (maltolato) oxovanadium (IV) (BMOV), an organic vanadium compound, on plasma glucose levels by several routes of administration.
Ref: Can J Physiol Pharmacol. 1995 Jan;73(1):55-64.