This package includes a combination of effective antioxidants targeted for eye health including 15,000IU of Vitamin A (as Beta Carotene), along with a range of other important antioxidants including: Vitamin C, alpha lipoic acid, l-carnitine, CoQ10, bilberry and lutein, as well as Carlson's omega-3 fatty acids.
Package content includes:
Vitamins A and E
A 1993 study (Berson and others) found a significant beneficial effect for 15,000 IU of vitamin A supplements and a suggested adverse effect for 400 IU of vitamin E on the course of the common forms of RP. Larger doses of vitamin A were not associated with greater benefit.
A. Berson, Rosner, Sandberg, Hayes, Nicholson, Weigel-DiFranco, and Willette, 1993. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Archives of Ophthalmology (June 1993), volume 111(6), pages 761-772.
Vitamins E, C, alpha lipoic acid
An RP animal study determined that high dose antioxidants (vitamins E, C, alpha lipoic acid others) significantly reduced free radical damage in cones in the retina photoreceptor cells, increased cone cell density and preserved cone function. These results, according to the Johns Hopkins authors, suggest that the gradual cone death that occurs after rod cells die is due to free radical damage, and that antioxidants could be helpful.
Komeima K, et al. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. PNAS 103:1130-35, 2006.
Omega-3 Fatty Acids
While a 4 year long study reported that 1,200 mg of supplemental DHA along with high dose vitamin A did not slow the course of RP overall, further subgroup analysis showed benefit for those starting vitamin A supplementation for the first time. In addition, those study participants taking vitamin A (but not DHA) who also had a higher dietary omega-3 intake experienced substantial benefit. The rate of visual field decline was retarded by 40-50% yearly in those whose omega-3 intakes were equivalent to 1-2 servings of fatty fish weekly. Berson EL, et al. Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa. 12:1306-14, 2004.
Research suggests that supplementation with lutein improves visual field and may also modestly improve visual acuity.
Bahrami H, et al. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial. BMC Ophthalmology 6:23, 2006.
Other nutrient notes:
Alpha Lipoic Acid is a powerful fat and water-soluble antioxidant that helps to recycle vitamin C and indirectly recycle vitamin E, for more antioxidant protection. It is also an important factor in the energy production process in the cells.
L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria (the cellular energy producer) within the cell, where fats are oxidized to produce the cellular energy compound ATP.
CoQ10 is an essential component of healthy mitochondrial function. It also acts as an effective antioxidant, helping protect proteins, and DNA of mitochondria from oxidation and supporting mitochondrial function.
Bilberry extracts behave like antioxidant free radical fighters that not only protect nerve cells help suppress damage from sunlight and have been shown to improve microcapillary circulation. Microcapillary problems are often related to eye problems.