By Pure Encapsulations (Healthcare Practitioner Brands). Cardiovascular and antioxidant protection--
Tocotrienols (200 mg per day) may offer protection against atherosclerosis by preventing oxidative damage to LDL cholesterol. In a double-blind study in patients with severe atherosclerosis of the carotid artery, the main artery supplying blood to the head tocotrienol supplementation reduced the size of the atherosclerotic plaques; in contrast, none of the patients receiving the placebo showed an improvement in their atherosclerosis.-
*This formula provides a natural blend of 30% tocotrienols and mixed tocopherols extracted from rice bran oil. Tocotrienols are isoprenoid compounds related to the vitamin E family. While the structure of tocotrienols differs only slightly from vitamin E, it gives tocotrienols distinct functions of their own. In studies, tocotrienols have been shown to support cardiovascular health by helping to modulate HMG-CoA reductase activity, the primary enzyme of cholesterol synthesis.
Tocotrienols have demonstrated the ability to support human breast cell health and scavenge free radicals as well. Gamma tocotrienol is believed to be the most prized constituent. In addition, this formula contains alpha and gamma tocopherols, the active forms of vitamin E. A powerful antioxidant, vitamin E helps to preserve the cell membranes of cardiac and skeletal muscles. Vitamin E also plays a critical role in nucleic acid and protein metabolism, mitochondrial function, and hormonal support.-
This combination of tocotrienols and vitamin E provides potent, synergistic support for the cardiovascular system and antioxidant protection for cells.-
Ingredients: Each softgel capsule contains:
Suggested Use: 1-2 softgels per day, with meals.--
This study analyzed 3718 subjects aged over 65 years Project Chicago Health and Aging Project. Participants were evaluated over a period of six years. This study evaluated the relationship of the vitamin tocopherol intake with the incidence of Alzheimer's disease for 4 years.
--The conclusion of the study suggested that supplementing with various tocopherols, more than one intake isolated, protects against the development of Alzheimer's disease.
-Ref: Am J Clin Nutr, 2005;81:508-514
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
-The Gamma form of tocotrienols inhibited cholesterol formation in cell cultures by way of the mevalonate pathway.
-J Biol Chem. 1993 May 25;268(15):11230-8-
Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics
-Alpha and gamma forms of tocotrienols improve left ventricle function and reduce several hypercholesterolemic proteins.
Mol Cell Biochem. 2012 Jan;360(1-2):35-45. Epub 2011 Sep 15
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