Resveratrol (2015) & Alzheimer's
Learn more about Alzheimer's disease.
Resveratrol, a compound found in red wine, is known for its neuroprotective capacity. Researchers investigated whether it could be helpful in treating or slowing the development of Alzheimer's disease.
There are several biomarkers associated with Alzheimer's. Several of them are notable because as the condition worsens their presence in the body declines. In other words, as their levels get less, Alzheimer's is seen to progress in severity.
In a double-blind, placebo-controlled, randomized 1 year study of patients with moderate to mild Alzheimer's researchers assessed whether treatment with resveratrol made any noticeable difference. 119 patients were given placebo or resveratrol 500mg once a day. The doses of resveratrol were increased by 500mg every 13 weeks - and after a year the patients were taking 1000mg twice a day.
Brain MRI's and cerebral spinal fluid were sampled at the start of the study and at the end of the study. The progress of the resveratrol's absorption, distribution within the body, metabolism, and excretion was studied at the beginnning, every 13 weeks, and at the end of the year.
The researchers reported that the biomarker which normally declines as Alzheimer's progresses was lost less in the patients taking resveratrol. Surprisingly, brain volume also decreased - which is possibly due to reduced inflammation in the brain.
These results are not enough to recommend taking resveratrol, but they do merit further examination.
Researchers: R. Scott Turner, MD et al.
Published: A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease, Neurology, September, 2015.