Diabetic retinopathy is a leading cause of blindness among adults. Poor blood sugar balance can damage nerves, so nerve support is crucial for people with diabetes. Diabetic retinopathy is a serious eye condition stemming primarily from imbalances in blood sugar levels. When blood sugar is not properly managed, the body’s delicate nerve tissues, including the retina, can be injured.
At Natural Eye Care, we have examined the research on nutrients that help protect the eye, including the retina and blood flow to the eye. Research has identified oxidative stress and inflammation as key contributors to the onset and development of numerous eye conditions.1 2 3 These conditions include macular degeneration, glaucoma, cataracts, macular edema, and diabetic retinopathy. Without intervention, these eye diseases can result in a gradual decline in vision, potentially leading to blindness. Studies suggest that incorporating specific antioxidant and anti-inflammatory nutrients may be beneficial in preventing and managing these eye disorders.4
Having both diabetes and high blood pressure increases the likelihood of developing diabetic retinopathy. This combination also exacerbates retinopathy’s progression. Studies indicate that chronic inflammation and oxidative stress are significant contributors to diabetic retinopathy.5
Nutrients That Help Protect the Eyes
Anthocyanins
Anthocyanins are antioxidants found in red, purple, and blue fruits and vegetables. They help mitigate oxidative stress in the retina,6 and reduce inflammation in eye tissues.7 Additionally, anthocyanins offer antiviral, antiallergic, antimicrobial, and anticarcinogenic benefits.8 They support blood circulation and maintain the integrity of the eye’s fine capillaries. Furthermore, anthocyanins inhibit the formation of new blood vessels,9 a process associated with advanced stages of macular degeneration and diabetic retinopathy.
Alpha Lipoic Acid
Researchers are exploring the potential of alpha-lipoic acid and its derivatives as treatments for neuropathies linked to complications from both type 1 and type 2 diabetes, including diabetic retinopathy. The benefits of alpha-lipoic acid stem from its antioxidant properties10 and ability to protect against cell damage.11 Numerous studies and reviews have shown that alpha-lipoic acid is effective in managing diabetic neuropathy,12 13 with enhanced results when patients maintain proper blood sugar levels.14 15 16
Ashwagandha
Ashwagandha, an Ayurvedic herb, may contribute to eye health by enhancing microcirculation in the eyes, thereby boosting oxygen and nutrient delivery. It also supports nerve health. Research indicates that Ashwagandha possesses anti-inflammatory, antimicrobial, cardioprotective, and anti-diabetic properties.17
Berberine
Berberine is an alkaloid found in the Huanglian herb, known for its use over thousands of years in treating diabetes. Several studies have shown that taking 600–2,700 mg of berberine daily can lower fasting and long-term blood sugar levels by up to 20% and 12%, respectively,18 19 especially when combined with blood sugar medication. A review of 14 studies indicated that berberine is as effective as common blood sugar medications, such as metformin (Glucophage), rosiglitazone (Avandia), and glipizide (Glucotrol).20 One pilot study concluded that berberine is a potent oral hypoglycemic agent21 with a modest effect on lipid metabolism. It is safe, and the cost of treatment with berberine is very low, making it a potential new drug candidate for treating type 2 diabetes.
Bitter Melon
Also known as bitter gourd or Momordica charantia, bitter melon is a tropical vine related to the gourd family, including zucchini, squash, pumpkin, and cucumber. Rich in antioxidants, Bitter Melon aids in blood sugar management22 by lowering blood sugar levels and hemoglobin A1c,23 as well as significantly reducing fructosamine, a short-term indicator of long-term blood sugar control.24 It is believed to enhance the utilization of sugar in tissues and stimulate the secretion of insulin, the hormone that regulates blood sugar levels.25
Bilberry
Anthocyanosides are the active components of bilberry. Studies on bilberry found that this fruit protects the mitochondria, the battery of the cell.26
Bilberry
Bilberry was associated with increased macular thickness in people who had both diabetic retinopathy and macular degeneration.27 In patients with diabetic retinopathy, bilberry has been found to enhance light sensitivity[28.Ibid. Moshetova. (2015).] and delay the deterioration of the blood-retinal barrier.28 Studies indicate that berry extracts and anthocyanins can inhibit alpha-amylase and alpha-glucosidase enzymes in the gut. They interact with sugar transporters in the intestine, which slows the absorption of glucose into the bloodstream. This makes berry extracts and anthocyanins valuable for managing diabetes and diabetic retinopathy.29
Curcumin
Derived from turmeric, curcumin is noted for its anti-inflammatory properties, which have been the focus of numerous studies suggesting its potential benefits for diabetic retinopathy.30 31 Researchers are investigating the mechanisms behind these nutrient therapies. Curcumin helps reduce blood vessel leakage by inhibiting the CAMKII biochemical process.32 Additionally, it slows the death of islet cells, which produce insulin, by reducing the formation of islet free radicals in people with diabetes.33
Green Tea
Studies indicate that consuming green tea may offer protective benefits against diabetes complications.34 35 36
Lutein
Lutein, together with zeaxanthin and other essential carotenoids, is crucial for safeguarding the retina from oxidative stress, inflammation, and neurodegenerative harm. These compounds play a vital role in maintaining eye health and preventing damage.37
Lycopene
Lycopene is an antioxidant found in tomatoes, red bell peppers, and carrots. Individuals with diabetes often exhibit notably lower levels of lycopene.38
Resveratrol
Resveratrol, known for its anti-inflammatory properties, aids in managing diabetic retinopathy and heart disease by minimizing vascular inflammation.39 This compound may also support microcirculation in the eyes.40 By curbing inflammation, Resveratrol helps maintain biochemical equilibrium and offers protection to the nervous system.41
Resveratrol shows promise in managing type 2 diabetes by enhancing blood sugar regulation and reducing insulin resistance.42 43 44 These effects may contribute to lowering the risk of diabetic retinopathy.45 Its anti-inflammatory properties further aid in preventing diabetic retinopathy.46
Rutin
Rutin can potentially lower fasting glucose levels, which may help guard against elevated blood sugar.47 In this role, it could be beneficial in preventing the progression of diabetes into diabetic retinopathy.
Other beneficial nutrients include Vitamins B6, B12, B1, and B2, L-carnosine, CoQ10, essential fatty acids, Vitamin E, pine bark, taurine, Vitamin C, glutathione, Vitamin D, L-arginine, and gymnema sylvestre.
Maintain a Healthy Diet
Be sure to eat a healthy diet. We usually recommend the Mediterrean Diet.
Avoid unhealthy oils, such as fried food. Also, avoid trans-fatty acids, found in most chips, canned frosting, and margarine.
Some people may need to eliminate caffeine and alcohol.
Everyone should reduce sugar. All types of sweeteners can lead to inflammation. Excessive sugar intake is a significant factor in diseases like type 2 diabetes, cardiovascular disease, cancer, and dementia.48 Research has connected these health issues to eye diseases such as cataracts, glaucoma, and diabetic retinopathy. Additionally, high-glycemic diets have been linked to macular degeneration.49 50 Stop drinking soda pop and other sugary drinks.
Completely eliminate artificial sweeteners:
Aspartame (NutraSweet®, Equal®), Saccharin (Sweet’N Low®, SugarTwin®), Acesulfame K (Sunett®, Sweet One®, Sucralose (Splenda®)). Artificially-sweetened soft drinks, for example, have been linked to a higher risk of ischemic stroke, dementia, and Alzheimer’s disease.51 Stevia is fine.
Limit saturated fats, found in fatty meats and non-skim dairy products.
Juicing Recipe
Use a juicer to make your own healthy, nutrient-packed beverages at home. A combination of some of the following is good for diabetes: Ginger, asparagus, garlic, leeks, Jerusalem artichokes, spinach, parsley, beets, pumpkin, celery, carrots, cabbage, raspberries, chlorophyll. You can add your favorite fruits and vegetables but do not consume too much fruit.
Suggested Supplements
Dr. Grossman’s Circulation and Optic Nerve Support Formula
Advanced Eye & Vision Support Formula (whole food) 60 vcaps
Dr. Grossman’s Meso Plus Retinal Support and Computer Eye Strain Formula with Astaxanthin 90 vcaps
ReVision Formula (wild-crafted herbal formula) 2 oz
Dr. Grossman’s Blood Vessel Control Formula 2oz
Dr. Grossman’s Vitamin C Plant-Based Formula – 60 caps
Resveratrol Ultra High Potency 60 gels – Antioxidant
Dr. Grossman’s Premium Turmeric Vcaps (Organic)
Sugar Balance Packages
Sugar Balance & Blood Vessel Support Package 1 (1 month)
Sugar Balance & Blood Vessel Support Package 2 (3-month)
Recommended Books
Natural Eye Care Series: Macular Degeneration (paperback)
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- Kowluru, R.A., Mishra, M. (2015). Oxidative stress, mitochondrial damage and diabetic retinopathy. Biochem. Biophys. Acta. 1852:2474–2483. ↩
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- Mykkanen, O.T., Kalesnykas, G., Adriaens, M., Evolo, C.T., Torronen, R., et al, (2012). Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice. Mol Vis, 2012:18:2338-51. ↩
- Miyake, S., Takahashi, N., Sasaki, M., Kobayashi, S., Tsubota, K., et al. (2012). Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism. Lab Invest, Jan;92(1):102-9. ↩
- Ghosh, D., Konishi, T. (2007). Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function. Asia Pac J Clin Nutr, 2007;16(2):200-8. ↩
- Matsunaga, N., Tsuruma, D., Shimazawa, M., Yokota, S., Hara, H. (2010). Inhibitory actions of bilberry anthocyanidins on angiogenesis. Phytother Res, Jan;24 Suppl 1:S42-7. ↩
- Gomes, M.B., Negrato, C.A. (2014). Alpha-lipoic acid is a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr, Jul 28;6(1):80. ↩
- Kowluru, R.A., Odenbach, S. (2004). Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes, 2004 Dec;53(12):3233-8. ↩
- Lin, J., Bierhaus, A., Bugert, P., Dietrich, N., Feng, Y., et al. (2006). Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia, May;49(5):1089-96. ↩
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- Papanas, N., Ziegler, D. (2014). Efficacy of alpha-lipoic acid in diabetic neuropathy. Expert Opin Pharmacother, Dec;15(18):2721-31. ↩
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- Moshetova, L.K., Vorob’eva, I.V., Alekseev, I.B., Mikhaleva, L.G. (2015) Results of the use of antioxidant and angioprotective agents in type 2 diabetes patients with diabetic retinopathy and age-related macular degeneration. Vestn Oftalmol, May-Jun;131(3):34-44. ↩
- Kim, J., Kim, C.S., Lee, Y.M., Sohn, E., Jo, K., et al. (2015). Vaccinium myrtillus extract prevents or delays the onset of diabetes–induced blood-retinal barrier breakdown. Int J Food Sci Nutr, Mar;66(2):236-42. ↩
- Castro-Acosta, M.L., Lenihan-Geels, G.N., Corpe, C.P., Hall, W.L. (2016). Berries and anthocyanins: promising functional food ingredients with postprandial glycaemia-lowering effects. Proc Nutr Soc, Aug;75(3):342-55. ↩
- Aldebasi, Y.H., Aly, S.M., Rahmani, A.H. (2013). Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways. Int J Physiol Pathophysiol Pharmacol, Dec 15;5(4):194-202. ↩
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- Ibid. Abu-Amero. (2016). ↩
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- Ibid. Bola. (2014). ↩
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