In this dry eye study, it shows that the GLA group showed a significant improvement in the specific symptom of ‘dryness’ at 3 and 6 months (p <0.01) as well as significant improvement in overall lens comfort at 6 months (p<0.01). Tear meniscus height was increased in the GLA group at 6 months relative to baseline (p<0.01), although all other objective signs were unchanged.
GLA (gamma-linolenic acid), an omega-6 fatty acid with anti-inflammatory properties can be found in oils derived from black currant seeds and the evening primrose plant. Several small trials testing GLA and linoleic (LA) oil in dry eye syndrome with an inflammatory component report reduced ocular surface inflammation and symptom improvement.
1. Barabino, M et al. Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea 22:97?101, 2003.
2. Aragona P, et al. Systemic omega-6 essential fatty acid treatment and PGE1 tear content in Sjogren’s syndrome patients. Invest Ophthalmol Vis Sci 46:4474?9, 2005
3. Kokke KH, et al. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. Contact Lens Anterior Eye 31:141-6, 2008.
4. Macri A, et al. Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. Graefes Arch Clin Exp Ophthalmol 241: 561-6, 2003.
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