Lutein (2011, 2015) & Uveitis


Learn more about treating uveitis.


Researchers investigated the role of the antioxidants lutein and zeaxanthin on uveitis in lab animals.

The combination of the two powerful antioxidants acted to reduce certain cell extracts and lysates and inhibited signal pathways that are characteristic of uveitis.

The researchers concluded that these antioxidants should be explored for managing uveitis conditions.

Researchers: S.C. Chao, T. Vagaggini, et al.

Published: Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways, Journal of Ophthalmology, November, 2015.


Researchers have studied how antioxidants can support healing for the inflammatory condition uveitis. Lutein is known for its protection of the retina and other tissues of the eye. This study investigates how lutein functions in lab animals with uveitis.

Test mice were give lutein in their drinking water for five consecutive days, while controls were given plain drinking water before uveitis was induced.

The animals who received the lutein had significantly lower levels of nitric oxide and malondialdehyde content (both are indicative of inflammation).

Furthermore, the animals who received lutein demonstrated increased activity and ability to absorb vitamin C, glutathione, superoxide dismutase and glutathione peroxidase. Lutein also improved the expression of other necessary mineral in the mice.

The researchers concluded that Lutein's antioxidant properties contributed to fighting the inflammatory response characteristic of uveitis.

Researchers: R.R. He, B. Tsoi, et al.

Published: Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice, Chinese Medicine, October, 2011.