Acetyl-L-Carnitine (1994-2017) & Alzheimer's Disease
In pretreatment acetyl-l-carnitine has been shown to increase mitochondrial biogenesis and decrease production of free radicals. Since the late 1990s, it has been demonstrated that it slows the development of AD. It reduces the ill effects of high levels of homocysteine, lessens physical and mental fatigue, and improves cognitive functioning. It may raise the levels of nerve growth factor and increase the activity of acetylcholine (it is a precursor of acetylcholine), a neurotransmitter that is critical to healthy brain function. ALA supports neurogenesis (production of new neurons) in the brain resulting in improvements in memory and learning as well as mental status and cognitive function.
A small double-blind placebo-controlled 12 twelve-week trial, using 2250 to 3000mg daily found that neuropsychological tests (MMSE, CGI, etc) was markedly better than placebo, and did not depend on the baseline cognitive impairment. The researchers recommend it for early stages of Alzheimer's and vascular dementia.
Combined with alpha lipoic acid, it is more effective.
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