Alpha Lipoic Acid (1999-2018) & Alzheimer's


Alpha lipoic acid (ALA) hs been called the "universal" antioxidant because it boosts glutathione levels in cells already within a normal range, and has potent antioxidant actions, reducing oxidative stress.

The alpha R form is the one most easily utilized by the body. Supplementation with alpha lipoic acid inhibits progress of tau protein toward fibrils of plaque, reduces cognitive decline, lipid peroxidation, inflammation, and tau-induced iron overload.

Its therapeutic potential for different neurodegenerative diseases, including Alzheimer's is due to improved mitochondrial function in Alzheimer's, and Parkinson's. It protects against age-related cognitive dysfunction for those with AD and other neurodegenerative conditions. Studies aiming to assess the neuroprotective effects of LA on behavioral outcomes show that LA can reduce memory deficits in different behavioral paradigms of AD.


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