DHA/EPA Protects Against Inflammation

research DHA, a component of omega-3s, reduces inflammation and so may reduce stress caused by inflammation in the retina seen in diabetic retinopathy. DHA is also a precursor for a biochemical compound known as neuroprotectin D1, which also helps protect against damage from inflammation and reduces cell death within the retina. Bazan, N.G. (2006). Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Adv Exp Med Biol, 572:531-40. Bazan, N.G., Molina, M.F., Gordon, W.C. (2011). Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. Annu Rev Nutr, Aug 21;31:321-51. Mukherjee, P.K., Marcheselli, V.L., Serhan, C.N., Bazan, N.G. (2004). Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci USA, Jun 1;101(22):8491-6 Chen, W., Esselman, W.J., Jump, D.B., Busik, J.V. (2005). Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci, Nov;46(11):4342-7.