The breast cancer drug tamoxifen may lead to eye problems in women over age fifty. An article in Breast Cancer Research and Treatment reported that the drug can cause physical changes to the eye itself, specifically by shrinking the optic cup. The optic cup is the depression in the eye nearest to where the optic nerve exits on its way to the brain. A previous study had indicated that about 13% of tamoxifen users report vision changes.
Lead study author Alvin Eisner, PhD told Medscape: “Clinicians need to be aware that if patients on tamoxifen are complaining of vision problems, these concerns need to be taken seriously.”