Dry Macular Degeneration May Be Treated by Anti-Placental Growth Factor Antibody, Aflibercept

senior citizen macular degenerationAflibercept is currently a treatment for wet Age-Related Macular Degeneration (AMD), but it may also prove useful for patients with dry AMD.

The researchers accidentally discovered that an anti-placental growth factor antibody could provide retinal protection for the dry form of Macular Degeneration. They tried using a known protein called placental growth factor (PlGF) on a simulation of wet AMD in animal tissues. The PIGF made the retinal cells worse. So, they tried an anti-PlGF antibody treatment. This treatment provided protection against retinal damage.

Aflibercept is an anti-PlGF antibody treatment. It is used to treat wet AMD, macular edema and diabetic retinopathy. Since it is an existing and approved drug, it can be quickly evaluated in clinical trials for a new use with dry AMD patients.

Dry Macular Degeneration is more common than Wet AMD (also known as choroidal neovascularization). Macular Degeneration means that central part vision is damaged and gradually lost over time. It is especially prevalent in senior citizens, interfering with quality-of-life factors such as driving, reading, writing, recognizing faces, cooking and living independently.

nutrients Related: Lifestyle can have a significant impact on ARMD.

Study: “Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice.” by Hiroshi Izawa, Yuki Inoue, Yuta Ohno, Kazuki Ojino, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara. Invest Ophthalmol Vis Sci 2015 Oct;56(11):6914-24

Article Name
Dry Macular Degeneration May Be Treated by Anti-Placental Growth Factor Antibody, Aflibercept
Anti-placental growth factor antibody Aflibercept may help dry AMD.
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About Marc_Grossman

Marc Grossman, Doctor of Optometry and New York State Licensed Acupuncturist, is a holistic eye doctor and co-author of a number of books on natural vision care. Since 1980 Dr. Grossman has been helped many people maintain healthy vision and even improve eyesight. He is dedicated to providing information to those with conditions ranging from myopia and dry eyes to potentially vision threatening diseases such as macular degeneration and glaucoma. His combined multi-disciplinary approach using nutrition, eye exercises, lifestyle changes and Chinese Medicine provides him with a wide array of tools and approaches with which to tackle difficult eye problems.