Carnosine (1999, 2009) combats cataracts

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Chinese and Russian researchers completed a preliminary study whose result showed that carnosine gives a pronounced effect on primary senile cataracts, the effective rate being 100%. For mature senile cataracts, the effect rate was 80%.

Researchers: A.M. Wang, et al.

Published: Use of carnosine as a natural anti-senescence drug for human beings. Department of Biochemistry and Department of Neurobiology, Harbin Medical University, China, 1999.


Italian researchers report that carnosine may be valuable in preventing and treating cataracts. Carnosine is a dipeptide composed of the amino acids beta-alanine and histidine, especially found in muscle and brain tissue.

The researchers tested two forms of carnosine, d- and l-carnosine, on the primary protein that forms lens structure (from cows). The protein cultures were treated with guanidine, a compound that causes cataracts by forming fine alpha-crystallin fibers, known as fibrils. They also found that when they treated the cultures with d- or l- carnosine such fibril formation was inhibited. Adding carnosine to already existing fibrils almost completely dissolved them.

Researchers: F. Attanasio, S. Cataldo, S. Fisichella, S. Nicoletti, V.G. Nicoletti, B. Pignataro, A. Savarino, E. Rizzarelli, University of Catania.

Published: Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease, Biochemistry, July 14, 2009