CoQ10 ('01, '02, 2015) & Hypertension
Scientists report that high blood pressure increases certain biochemicals (cytokines) and stimulates an inflammatory response in the body. This study addresses the effect of CoQ10 in reducing cytokine levels and decreasing inflammation.
The test subjects were 60 patients with mild hypertension. The study lasted for 3 months and was randomized, double-blind, and placebo-controlled. The test group patients received 100mg CoQ10 daily. The placebo group received 100mg of lactose. Blood pressure and biomarkers for high blood pressure were tested at beginning and at the end of the 3 month period.
CoQ10, taken daily, reduced some pro-inflammatory markers but did not significantly change cytokines.
Researchers: N.B. Nesami, H. Mozaffari-Khosravi, et al
Published: International Journal for Vitamin and Nutrition Research, 2015.
The researchers wanted to look at supplementing with coenzyme Q10 (CoQ10) for subjects with both high blood pressure and type II diabetes.
They assigned 74 type II diabetes and high cholesterol patients to 4 groups in a random, double-blind, placebo-controlled study. For 12 weeks the groups took 100mg COQ10 (2x daily), or 200mg fenofibrate (1x daily) or both or neither. Fenobribrate is a drug more commonly used for high cholesterol. They evaluated the results by looking at blood pressure, long-term glycemic control and oxidative stress.
They found that there was a 3x increase in blood levels of CQ10 concentration and that systolic and diastolic blood pressure were markedly reduced. They found that fenofibrate did not change blood pressure. They also found that the improvements would possibly improve long-term blood sugar balance but did not result in reduced oxidative stress as measured by F2-isotopes.
Researchers: J.M. Hodgson, G.F. Watts, et al
Published: Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes, European Journal of Clinical Nutrition, November, 2002.
This was a 12 week double-blind, random, placebo-controlled study treating 46 men and 37 women with high blood pressure. They were given COQ10 for 12 weeks.
The reduction in systolic blood pressure was 17.8 +/- mm Hg. None of the subjects had experienced feeling dizzy when they stood up suddenly. The researchers determined that COQ10 was safely used as an alternative treatment option.
Researchers: B.E. Burke, R. Neuenschwander, et al
Published:Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension, Southern Medical Journal, November, 2001.