Alpha Lipoic Acid (2006) & Diabetes Mellitus

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Researchers evaluated whether oral alpha lipoic acid would improve insulin sensitivity in type 2 diabetic patients.

The researchers treated 12 patients over four weeks, and 12 subjects with normal glucose tolerance served as a control group. After four weeks, the insulin sensitivity of the diabetics was significantly improved (M from 3.202+/-1.898 to 5.951+/-2.705 mg/kg/min (mean+/-sD), p<0.01; and IsI from 4.706+/-2.666 to 7.673+/-3.559 mg/kg/min per mIU/l x 100 (mean+/-sD), p<0.05.) The difference was not significantly different between the treated patients and the control group after the end of the period.

Researchers: Kamenova P., Department of Diabetology, University Hospital of Endocrinology, Medical University, Sofia, Bulgaria

Published: Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid, Hormones (Athens). 2006 Oct-Dec;5(4):251-8.