*Bacopa monnieri (2008-2019) & Alzheimer's

Bacopa may be especially valuable for brain functioning.

Bacopa monnieri extract (Brahmi). Bacopa monnieri is known to have neuroprotective and cognition enhancing effects and has traditionally been a therapy for Alzheimer's disease. It improves circulation to the brain, improves mood, cognitive function, and general neurological function. Bacopa extract protects neurons from beta-amyloid-induced cell death by suppressing cellular acetylcholinesterase activity, and reduces oxidative stress by inhibiting release of proinflammatory cytokines from microglial cells (in vitro). It protects cells from oxidative damage from free radicals and DNA damage in the hippocampus, reduces lipid oxidation, is comparable to donepezil (and other drugs) in reducing anticholinesterase activity.

Abdul Manap AS, Vijayabalan S, Madhavan P, Chia YY, Arya A, et al. (2019). Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies. Drug Target Insights. Jul 31;13:1177392819866412.
Shinde P, Vidyasagar N, Dhulap S, Dhulap A, Hirwani R. (2015). Natural Products based P-glycoprotein Activators for Improved B-amyloid clearance in Alzheimer's Disease: An in silico Approach. Cent Nerv Syst Agents Med Chem. 2015;16(1):50-9.
Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. (2010). Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. J Ethnopharmacol. Jan 8;127(1):26-31.
Limpeanchob N, Jaipan S, Rattanakaruna S, Phrompittayarat W, Ingkaninan K. (2008). Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. J Ethnopharmacol. Oct 30; 120(1):112-7.
Nemetcheck MD, Stierle AA, Stierle DB, Lurie DI. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. J Ethnopharmacol. Feb 2;199:92-100.
Chaudhari KS, Tiwari NR, Tiwari NR, Sharma RS. (2017). Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease. Ann Neurosci. May;24(2):111-122.

On the basis of earlier studies researchers noted bacopa's ability to inhibit toxicity from tau, concluding that it can be used as a lead formulation in treating Alzheimer's and other neurological conditions.

Dubey T, Chinnathambi S. (2019). Brahmi (Bacopa monnieri): an ayurvedic herb against the Alzheimer's disease. Arch Biochem Biophys. Nov 15;676:108153.

Researchers further identify clinical applications, actions within and against cells, phytochemistry and biological applications indicating efficacy of bacopa as a therapeutic tool against Alzheimer's disease.

Manap ASA, Vijayabalan S, Madhavan P, Chia YY, Arya A, et al. (2019). Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies. Drug Target Insights. Jul 31;13:1177392819866412.