Rutin (2013-16, '18, '19) & Neurodegenerative Disorders

Rutin has a potential protective role in neurodegenerative disorders, such as AD,^{1, 2, 3} due to its capacity as a potent antioxidant^{4, 5, 6} with a strong effect on processing and clumping of amyloid beta, and changes to the oxidant-antioxidant balance linked to nerve cell death.⁷

In related research rutin in a sodium solution (for better absorbability) enhanced removal of amyloid beta, supported mitochondria, and reduced neuroinflammation, making it a potential therapy for Alzheimer's.⁸

Research

1. Park SE, Sapkota K, Choi JH, Kim MK, Him YH, et al. (2014). Rutin from Dendropanax morbifera Leveille protects human dopaminergic cells against rotenone induced cell injury through inhibiting JNK and p38 MAPK signaling. Neurochemical Res. Apr;39(4):707-18.
2. Magalingam KB, Radhakrishnan A, Haleagrahara N. (2013). Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Int J Mol Med. Jul;23(1):235-40.
3. Wang YB, Ge ZM, Kang WQ, Lian ZX, Yao J, Zhou CY. (2015). Rutin alleviates diabetic cardiomyopathy in a rat model of type 2 diabetes. Exp Ther Med. Feb;9(2):451-455.
4. Ibid. Park. (2014).
5. Yu XL, Li YN, Zhang H, Su YJ, Zhou WW, et al. (2015). Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress. Food Funct. Oct;6(10):3296-306.
6. Enogieru AB, Haylett W, Hiss DC, Bardien S, Ekpo OE. (2018). Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. Oxid Med Cell Longev. Jun 27;2018:6241017.
7. Hablemariam S. (2016). Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-73.
8. Pan RY, Ma J, Kong XX, Wang XF, Li SS, et al. (2019). Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-B clearance. Sci Adv. Feb 27;5(2):eaau6328.