Retinal Support & Vitamin A

Symptoms   Treatment   Complementary treatment   Photoreceptors

While vitamin A is generally recommended to help heal retinal conditions, there are some inherited forms of retinal deterioration where impaired utilization of vitamin A results in deposits in the photoreceptor layer of the retina.

Vitamins
& Supplements

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Stargardt's Package 1 (3-month supply)Stargardt's Package 1 (3-month supply)
Advanced Vision Support, Fish Oil & Lycopene
Essential
Advanced Eye & Vision Support (whole food) Formula 60 vcapsAdvanced Eye & Vision Support (whole food) Formula 60 vcaps
Whole food, wild crafted herbal vegetarian formula with vision antioxidants, chemical and preservative free.
Don't miss the multiple bottle discounts

Essential

Krill Oil with 8mg of astaxanthin per 2 capsules
Essential
Lycopene 15 mg 60 gelsLycopene 15 mg 60 gels
Red pigmented carotenoid, fights free radicals.
Essential
Microcurrent Stimulation 100ile Purchase OptionMicrocurrent Stimulation 100ile Purchase Option
helps improve circulation & reduce waste build-up
Essential
Saffron 2020 30 vcaps per bottleSaffron 2020 30 vcaps per bottle
Supports circulation, fights photo-oxidative damage, supports nerve synapses. This product is OUT OF STOCK. Please see Saffron Optimized 60 Vcaps as the replacement.
Very Important
Macular Degeneration Homeopathic Pellets

The condition arises through gene mutations and can cause conditions such as autosomal recessive Stargardt, cone-rod dystrophy, fundus flavimaculatus, retinitis pigmentosa and macular degeneration. This type of gene mutation is diagnosed in 1 in 20,000 children over 6, usually identified before age 20.

Conventional Treatment

Currently, there is no effective treatment for Stargardt disease, although in the future bone marrow stem cell injections may be a therapy. Research does suggest that supplementation with betacarotene and Vitamin A should be avoided as those with Stargardt have difficulty breaking down this vitamin in the eyes. This can result in additional toxicity to the retina.

Current research shows that UV-protective sunglasses can help slow the progression of Stargardt disease. Researchers have observed that mice with a mutation of their ABCR gene who were reared in dark environments had almost no lipofuscin deposits. Researchers are investigating whether injection of human embryonic stem cells has some benefit.

Scientists at Columbia University found that they could treat mice with ABCA4 mutations with vitamin A which had been enriched with deuterium (a stable hydrogen isotope) and found that the clumping effect of vitamin A was slowed considerably.1, 2

Complementary Treatment

  • No extra vitamin A: People with Stargardt cannot make an enzyme to get rid of the waste products from metabolized Vitamin A analogs and the build up of these waste products leads to the death of retinal cells, so supplementing with Vitamin A should be avoided.3

  • Favor the carotenoids that do not convert to vitamin A:lutein, zeaxanthin, astaxanthin and lycopene. Beta-cryptoxanthin are carotenoids that can be converted to Vitamin A in the body and therefore should be minimized in a Stargardts diet.

  • Limit foods highest in beta-carotene. Beta-cryptoxanthin are carotenoids which convert to vitamin A and should be minimized in a Stargardt diet.
    • Yellow foods. These carotenoids are typically found in yellow foods, such as corn and bell peppers, and are present in yellow-colored dairy products,such as egg yolks and butter, cantaloupe, mangoes, papaya, carrots, and sweet potatoes.
    • Green foods. Other foods to watch out for: peppers (hot and red), raw lettuce, kale, spinach, dandelion greens, pokeberry shoots, mustard greens, turnip greens, Chinese cabbage, chard, collards, watercress, beet greens, chicory, parsley, basil. (Ordered by content [.063 to .025 grams/200 calorie serving]). See detailed info. Tomatoes, asparagus, broccoli, celery and other cabbages are also high in beta-carotene, but less so.
  • Limit meats highest in vitamin A/Beta-carotene: Beta-carotene is stored in the liver so avoid eating liver, especially moose liver, turkey liver, and duck liver as well as veal (ordered by content [1000043IU to 53951IU per 200 calorie serving]): See detailed info.
  • Limit vegetables highest in vitamin A: hot taco sauce, broccoli, peppers, carrots, mustard spinach, lettuce, kale, pumpkin, spinach, dandelion greens, pokeberry shoots, turnip and mustard greens, Chinese cabbage, corn salad, chard, collards, coriander/cilantro, watercress, beet greens, winter squash, lambsquarters. (ordered by content [1000043IU to 53951IU per 200 calorie serving]): See detailed info. Tomato, amaranth greens, and purslane are also high in vitamin A, but less so.
  • Limit fruits highest in Vitamin A: cantaloupe, apricots, Surinam cherry, tangerines, loquats, ohelo berries , grapefruit, sour cherries, persimmons, plums, peaches, watermelon, passion fruit juice, ground cherries, mango nectar, rose apples. (Lesser amounts, ordered by content [19899IU to 2712IU per 200 calorie serving]). See detailed info.
  • Alpha and gamma carotene also has some vitamin A activity, but not as much as beta-carotene. Beta-carotene produces twice as much vitamin A as alpha-carotene.
  • Limit saturated fat. Eating greater amounts of saturated fat and cholesterol appear to increase the risk of Stargardt.
  • Include Omega-3 fatty acids. Stargardt patient diets have been found to be deficient in EPA and DHA, omega-3 fatty acids. Supplementation with DHA may be helpful.4
  • Some research indicates that Microcurrent Stimulation (MCS) can be helpful. 5

Research

See research on Stargardt disease. In addition, some research on macular degeneration may be relevant.

Footnotes

1. Deuterium Enrichment of Vitamin A at the C20 Position Slows the Formation of Detrimental Vitamin A Dimers in Wild-type Rodents, Yardana Kaufman, et al, March 11, 2011 The Journal of Biological Chemistry, 286, 7958-7965.
2. C20-D3-vitamin A Slows Lipofuscin Accumulation and Electrophysiological Retinal Degeneration in a Mouse Model of Stargardt Disease, Li Ma, et al, March 11, 2011 The Journal of Biological Chemistry, 286, 7966-7974.
3. Francesco Sofi, et al., Dietary profile of patients with Stargardt's disease and Retinitis Pigmentosa: is there a role for a nutritional approach? BMC Ophthalmology, January, 2016.
4. Giuseppe Querques, Pascale Benlian, Bernard Chanu, et al, DHA supplementation for late onset Stargardt disease: NAT-3 study, Clinical Ophthalmology, June, 2010. 5. Edward Paul, O.D., Ph.d., et al, Medicine, The Treatment of Retinal Disease With MCS and Nutritional Supplementation, International Society for Low-Vision Research and rehabilitation at the Low Vision Congress in Gothenberg, Sweden 2002.